Agriculture of the upper and lower Uele district, Democratic Republic of the Congo is still under exploitation, present study has been carried out to exploit the factors responsible for the under exploitation of Uele district agriculture. This study also aimed to find out possible solution to overcome these factors and promote the agriculture of study area. Results of the study revealed the various factors like social, political, administrative, economic, environmental and technical field are responsible for the under exploitation of the Lower and Upper-Uele districts agriculture. To overcome these problems like other countries agricultural sector should have its own solid budget. With this conscientization and planification of the adapted agricultural policies and politics are required on the priority basis. Furthermore, popularization and distribution of genetically developed seeds or rustic parents, empowerment of the agriculture based research, relaunching of agriculture, formation and distribution of market values of agriculture product and agrarian reform literacy are the possible solution for the promotion of Lower and Upper Uele districts agriculture. Proper dissemination of well acceptable agricultural policies between farmers and general population is must. For sustainable agricultural development, a strong complementarity between public and private investors is necessary.